Test your knowledge of prophylactic strategies in selected high-risk or outpatient CAR-T populations

Ciltacabtagene autoleucel has demonstrated high response rates in relapsed/refractory multiple myeloma but is associated with high rates of which toxicity?
Cytokine release syndrome
Hypothyroidism
Kidney stones
Alopecia
Which of the following can be administered prophylactically to mitigate the risk of cytokine release syndrome?
Fludarabine
Cyclophosphamide
Ruxolitinib
Tocilizumab
Which of the following is the hallmark symptom of cytokine release syndrome?
Pruritic urticarial rash
Fever
Bronchospasm with wheezing
Hyperglycemia
Which of the following are potential benefits of prophylactic tocilizumab?
Reduced risk of cytokine release syndrome
Reduced risk of hypotension or hypoxia
Increased rates of successful outpatient management
All of the above
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