Test your knowledge of isolated brain metastasis in BRCA2-mutated HR+ HER2- breast cancer

Which clinical and pathological features in this case report indicate that the patient was at high risk for developing distant metastatic disease?

Ki-67 proliferation index of 75%

Oncotype DX recurrence score of 37

Histologic grade 3

All of the above

Patients with BRCA2 mutant breast cancer are at a higher risk of developing brain metastasis than patients with BRCA1 mutant breast cancer.

True

False

Olaparib can be given in the adjuvant setting to patients with a germline BRCA1 or BRCA2 pathogenic or likely pathogenic variant, according to the defining characteristics listed in the OlympiA trial?

True

False

Which PARP inhibitor is associated with greater hematologic toxicity?

Olaparib

Talazoparib

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