Quiz #2

Which driver mutation is most commonly present in patients with PV?
MPLW515L
FLT3
CALR exon 9
JAK2 V617F
A 65-year-old patient is referred to your clinic for erythrocytosis. In your diagnostic workup of the patient, you want to eliminate secondary causes for the increase in red blood cells. Which laboratory result would help confirm your diagnosis of PV?
Low serum erythropoietin
Increased serum iron levels
Thrombocytopenia
Results of a bone marrow aspiration and biopsy are considered major diagnostic criteria for PV based on the World Health Organization (WHO) 2016 Guidelines. What would you expect to see in the bone marrow?
Increased myeloblasts
Reticulin fibrosis
Hypercellular marrow with trilineage myeloproliferation
Ringed sideroblasts
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