Test your knowledge of Avapritinib Response in PDGFRA Exon 18 GIST Management

Which specific PDGFRA mutation is known to confer resistance to imatinib therapy?
Exon 18 missense variant
Exon 12 mutation
Wild-type PDGFRA
PDGFRA D842v mutation
Adjuvant therapy is recommended for gastrointestinal stromal tumors (GISTs) confirmed to harbor a PDGFRA mutation.
True
False
In GIST cases driven by a PDGFRA mutation, approximately 80% of these mutations are found in which specific exon?
Exon 12
Exon 14
Exon 18
Exon 17
Avapritinib is a tyrosine kinase inhibitor (TKI) approved for use against PDGFRA-mutated GISTs, demonstrating efficacy in the phase I NAVIGATOR trial. What is the recommended neoadjuvant therapy dose for avapritinib?
100 mg daily
300 mg daily
400 mg daily
600 mg daily
0
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