MPN Quiz #6

Case Study: Mr. M is a 45-year-old male diagnosed with myelofibrosis who has fatigue, dyspnea, and left upper quadrant abdominal discomfort with certain movements. Abdominal imaging reveals splenomegaly. The spleen is minimally palpable on exam. Labs reveal mild leukocytosis without blasts, elevated LDH, anemia, and normal platelet count.
Case Study: Mr. M is a 45-year-old male diagnosed with myelofibrosis who has fatigue, dyspnea, and left upper quadrant abdominal discomfort with certain movements. Abdominal imaging reveals splenomegaly. The spleen is minimally palpable on exam. Labs reveal mild leukocytosis without blasts, elevated LDH, anemia, and normal platelet count.
What would prompt you to think about starting treatment for Mr. M?
Elevated LDH
Age
Normal platelets
Splenomegaly
Would starting a JAK inhbitor be a good option for Mr. M?
Yes
No
What supportive care measures may Mr. M need as he starts therapy?
Antibiotics
Proton pump inhibitor
Red blood cell transfusions
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