How Much Have You Learned This Year?

The 2-year follow-up of the STARGLO study (glofitamab + GemOx) in relapsed/refractory DLBCL showed which of the following?
High rates of treatment discontinuation due to toxicity
Durable complete responses with manageable safety profile
Inferior outcomes compared to GemOx alone
No patients achieved response beyond 12 months
In the real-world, multicenter cohort study of pola-R-CHP for previously untreated DLBCL, what key finding was reported?
Inferior outcomes compared to R-CHOP
Comparable safety and efficacy to the POLARIX trial results
Higher rates of cardiac toxicity than expected
No benefit observed in high-risk subgroups
ML is a 74-year-old retired male rancher with a history of hypertension and obesity. He presents with progressive right hip pain and swelling that acutely worsened after a fall from his horse, leading him to the emergency department. Which of the following is the most likely initial diagnosis based on ML’s presentation?
Osteoporotic hip fracture
Primary bone diffuse large B-cell lymphoma (PB-DLBCL)
Subcutaneous hematoma from trauma
Osteomyelitis of the femur
The 5-year analysis of the POLARIX trial confirmed what long-term outcome with pola-R-CHP compared to R-CHOP?
No difference in progression-free survival
Persistent progression-free survival benefit without new safety signals
Inferior overall survival
Increased late toxicities
Which targets are engaged by the bispecific antibodies epcoritamab and glofitamab in the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL)?
CD3 on T cells and CD20 on B cells
CD19 on B cells and PD-1 on T cells
CD3 on T cells and CD19 on B cells
CD20 on B cells and PD-L1 on tumor cells
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