JADPRO MPN Case Study: Quiz #1

Which of the following clinical features contribute to this patient’s diagnosis of high-risk myelofibrosis? Choose all that apply.
Congestive heart failure
Presence of peripheral blasts
History of polycythemia vera
Leukocytosis
All patients with high-risk myelofibrosis who develop pneumonia must be admitted.
True
False
Pseudoprogression can be seen in patients with myelofibrosis who present with increased leukocytosis in the setting of infectious symptoms. If you encounter this scenario, what is the next best step?
Stop current therapy; it’s not working anymore
Search for underlying infection, treat appropriately, and monitor for response
Repeat a bone marrow biopsy
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