DLBCL Resource Center - Quiz 2

What is the main chemotherapy regimen used for frontline treatment of DLBCL?
R-EPOCH
R-CHOP
HyperCVAD
What are the agents used in R-CHOP?
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone
Revlimid, cyclophosphamide, doxorubicin, vincristine, and prednisone
Rituximab, cytarabine, doxorubicin, vincristine, and prednisone
Rituximab, cyclophosphamide, doxorubicin, vinblastine, and prednisone
Why is prednisone utilized in combination with chemotherapy?
Prednisone decreases the risk of neutropenia.
High-dose corticosteroids can result in increased appetite. Prednisone is used to maintain oral intake of food to ensure adequate nutrition for patients on chemotherapy.
Use of prednisone results in stimulation of programmed cell death, which can result in decreased adenopathy.
What is a reason to utilize dose-adjusted R-EPOCH?
If the patient has advanced stage disease
If the patient has CNS involvement
Presence of C-MYC, BCL-2, or BCL-6 mutations
All of the above
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