How much have you learned this year?

Which of the following is a common but severe toxicity associated with CAR T-cell therapy?
Tumor lysis syndrome
Cytokine release syndrome
Graft-versus-host disease
Hypercalcemia
What is the primary mechanism behind cytokine release syndrome in CAR T-cell therapy?
Tumor necrosis factor blockade
Massive cytokine secretion by activated CAR-T cells
Complement activation
Direct tumor lysis by natural killer cells
Which medication is used a first-line treatment for severe cytokine release syndrome?
Rituximab
Tocilizumab
Cyclophosphamide
Anakinra
Which atypical neurotoxicity has been reported following CAR T-cell therapy?
Guillain-Barré syndrome
Bell’s palsy
Lambert-Eaton syndrome
Huntington-like chorea
Cognitive decline after CAR T-cell therapy is most often associated with which syndrome?
Immune effector cell-associated neurotoxicity syndrome
Cytokine release syndrome
Hemophagocytic lymphohistiocytosis–like syndrome
Tumor lysis syndrome
Which strategy is commonly used for patients of the Jehovah’s Witness faith who decline blood transfusion?
Recombinant clotting factors and erythropoiesis-stimulating agents
Plasma exchange
Autologous blood storage
Whole blood substitutes
What recent U.S. Food and Drug Administration change may expand CAR-T access beyond academic centers?
Approval of CAR-T for all solid tumors
Removal of Risk Evaluation and Mitigation Strategies (REMS) requirements for CAR-T products
Elimination of hospitalization after infusion
Authorization of CAR-T self-administration
What are some ways in which the removal of Risk Evaluation and Mitigation Strategies (REMS) may affect community oncologists?
Allowing CAR-T administration without any monitoring
Reducing administrative burden and potentially improving access
Eliminating the need for tocilizumab availability
Guaranteeing reimbursement for CAR T-cell therapy
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