Test your knowledge of ruxolitinib discontinuation syndrome

What is the recommended strategy to prevent ruxolitinib discontinuation syndrome when transitioning from ruxolitinib to another JAK inhibitor?
Tapering off ruxolitinib then initiating a different JAK inhibitor with or without corticosteroids
Tapering off ruxolitinib while gradually up-titrating a different JAK inhibitor
Transitioning immediately from ruxolitinib to another JAK inhibitor without a taper or washout period
All of the above are possible transition strategies
Which of the following signs or symptoms is NOT associated with ruxolitinib discontinuation syndrome?
Fever
Splenomegaly
Respiratory distress
Hypertension
What is the primary treatment for ruxolitinib discontinuation syndrome in emergent scenarios?
Immediate initiation of antibiotics
Corticosteroids and reinitiation of ruxolitinib therapy
Blood transfusions and chemotherapy
Monitoring without intervention
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