Test your knowledge on Ph+ acute lymphoblastic leukemia

What is the primary genetic abnormality found in Ph+ B-cell ALL?
BCR:ABL fusion gene
JAK2 mutation
TP53 deletion
MYC gene amplification
Which mutation is associated with resistance to most tyrosine kinase inhibitors (TKIs) in Ph+ ALL patients?
T790M mutation
T315I mutation
V600E mutation
BCR::ABL fusion mutation
Which of the following is NOT an option for treating Ph+ ALL with the T315I mutation? 
Ponatinib
Olverembatinib
Dasatinib
Asciminib
What is the primary advantage of using next-generation sequencing (NGS) such as ClonoSEQ® in monitoring Ph+ ALL?
It is more sensitive than RT-PCR for detecting low-level BCR::ABL transcripts
It is less expensive than RT-PCR
It can be used to identify genetic mutations in Ph+ ALL cells
It provides real-time monitoring of treatment toxicity
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